Search results for " inactive"
showing 9 items of 9 documents
Canakinumab in Systemic Juvenile Idiopathic Arthritis: Clinical Inactive Disease Rate and Safety in Italian Patients
2020
Introduction: Systemic juvenile idiopathic arthritis (sJIA) accounts for 10-20% of all patients with JIA. The demonstration of a key role of IL-1 and IL-6 in the pathogenesis of the disease, led to consider sJIA an autoinflammatory disease: this explain the successfully use of IL-1 and IL-6 inhibitors. While the efficacy and safety of anakinra in sJIA is widely documented, there are no reports on large series of patients treated with canakinumab outside of the setting of clinical trials. Objectives: The aim of this study was to evaluate clinical response rate and disease course of canakinumab in Italian cohort of patients with sJIA. Methods: This is a retrospective multicenter study. Demogr…
FISCAL POLICIES: LAW VERSUS ABUSE
2015
Creating a more efficient tax-collection system is a popular topic in the context of the public debate surrounding the revision of the Romanian Fiscal Code and the Romanian Fiscal Procedure Code. One cannot reduce tax rates without improving the tax-collection system. This objective can be achieved through the modernization of the tax administration. Proposed solutions involve a clear correlation between the Fiscal Procedure Code and Fiscal Code together with a harmonisation of the national law to the European Union law. On condition that the NAFA's workforce will possess the required skills and the necessary procedures in place, the risk that the taxpayers acting in good faith will "vanish…
Canakinumab in systemic juvenile idiopathic arthritis: real-world data from a retrospective Italian cohort
2021
Abstract Objective The objective of this study was to use real-world data to evaluate the effectiveness and safety of canakinumab in Italian patients with systemic JIA (sJIA). Methods A retrospective multicentre study of children with sJIA was performed. Clinical features, laboratory parameters and adverse events were collected at baseline, and 6 and 12 months after starting canakinumab. The primary outcome measure of effectiveness was clinically inactive disease (CID) off glucocorticoids (GCs) treatment at 6 months. Results A total of 80 children from 15 Italian centres were analysed. Of the 12 patients who started canakinumab in CID while receiving anakinra, all maintained CID. Of the 68 …
Mediterranean diet impact on cardiovascular diseases: a narrative review
2017
Cardiovascular disease (CVD) accounts for more than 17 million deaths per year worldwide. It has been estimated that the influence of lifestyle on CVD mortality amounts to 13.7% for smoking, 13.2% for poor diet, and 12% for inactive lifestyle. These results deeply impact both the healthy status of individuals and their skills in working. The impact of CVD on productivity loss accounts for the 24% in total costs for CVD management. Mediterranean diet (MedD) can positively impact on natural history of CVD. It is characterized by a relatively high consumption of inexpensive and genuine food such as cereals, vegetables, legumes, nuts, fish, fresh fruits, and olive oil as the principal source of…
Les jeunes en situation de NEET : le rôle des compétences de base
2021
International audience; Enjeu prioritaire des politiques publiques nationales et européennes, les jeunes qui ne sont ni en emploi, ni en études, ni en formation connaissent un risque d’exclusion plus ou moins marqué selon les pays. Si le niveau d'éducation joue un rôle central dans ces situations, l’approche par les compétences de base permet d’affiner la focale. Les données internationales montrent en effet qu’un même niveau de diplôme ne certifie pas partout le même niveau de compétences. Comment s’expliquent ces écarts ? Dans quelle mesure ces compétences protègent-elles des situations de NEET indépendamment du diplôme ?
NOX2ko Mice Show Largely Increased Expression of a Mutated NOX2 mRNA Encoding an Inactive NOX2 Protein
2020
Background: The superoxide-generating enzyme nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX2 or gp91phox, the phagocytic isoform) was reported as a major source of oxidative stress in various human diseases. Genetic deletion is widely used to study the impact of NOX2-derived reactive oxygen species (ROS) on disease development and progression in various animal models. Here, we investigate why NOX2 knockout mice show no NOX2 activity but express NOX2 mRNA and protein. Methods and Results: Oxidative burst (NOX2-dependent formation of ROS) was measured by L-012-based chemiluminescence and was largely absent in whole blood of NOX2 knockout mice. Protein expression was still de…
Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PRE…
2019
Background: This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Methods: This is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55-75 years, BMI 27-40 Kg/m(2)) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had >= 3…
Unaccusativity
2012
Abstract My research is an attempt at suggesting a cross-linguistically valid definition of verbs characterized by unagentivity and affectedness such as “burn”, “die”, “sink”, “fall”, “slide”, etc., which according to the present analysis constitute the semantic core of unaccusativity. Both synchronic and diachronic approaches are followed. Various definitions have been attributed to these verbs (eventives, anticausatives, transformatives, inchoatives, decausatives). Although Perlmutter & Postal (1984) classify unaccusative verbs on the basis of their syntactic behavior, they also argue that the syntactic expression of arguments is always determinable on the basis of the meaning of the verb…
A possible desensitized state conformation of the human α7 nicotinic receptor: A molecular dynamics study
2017
International audience; The determination of the conformational states corresponding to diverse functional roles of ligand gated ion channels is subject of intense investigation with various techniques, from X-rays structure determination to electrophysiology and computational modeling. Even with a certain number of structures becoming recently available, only few major structural features distinguishing conductive open channel from the non conductive resting protein have been highlighted, while high-resolution details are still missing. The characterization of the desensitized conformation(s) is even more complex, and only few specific characteristics have been identified. Furthermore, exp…